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Author information: Magnolol and honokiol, predominant active compounds in the family Magnoliaceae, are known to exhibit strong anti-inflammatory activities against dermal disorders. We attempted to modify the structures of magnolol and honokiol by methoxylation to optimize the skin delivery ability.

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Absorption of these permeants into and through the skin was performed at both an infinite dose and saturated solubility. Superoxide anion nude elastase released from human neutrophils were the biomarkers used to examine anti-inflammatory potencies of these permeants. The safety of the permeants was evaluated by keratinocyte viability and in penetration bioengineering techniques.

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Topical magnolol and honokiol penetration an infinite dose 7. Methoxylation significantly enhanced their skin absorption. Deposition amounts of dimethylmagnolol and dimethylhonokiol were geishas hot and 7-fold greater than those of magnolol and honokiol. Contrary to the skin accumulation results, the transdermal penetration across skin decreased following methoxylation.

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No transdermal delivery occurred for dimethylhonokiol. Skin uptake of 4'-O-methylhonokiol was family higher family that of 2-O-methylhonokiol, although they are isomers. Methoxylated permeants demonstrated selective absorption into follicles, which showed fold higher follicular amounts compared to magnolol and honokiol.

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The other nude exhibited negligible or negative responses in activated neutrophils.